Hippocampus development

Across TCGA cell cohorts, RNA activity of the Hippocampus development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHF, KLHL25, and ZNF565, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SHF grouped by Hippocampus development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SHF →	+0.943	+0.218	.003	.004	3	4
OESOPHAGUS	KLHL25 →	+0.692	+0.252	.001	<.001	3	4
BREAST	ZNF565 →	+0.547	+0.392	<.001	.007	3	3
URINARY_TRACT	LRP3 →	+2.656	+0.320	<.001	.001	3	3
BONE	POP1 →	+1.432	+0.238	<.001	.004	3	3
BONE	PPAN →	+1.084	+0.272	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SHF by Hippocampus development activity — OVARY

Explore this box plot interactively →