Hippocampus development

Across TCGA cell cohorts, RNA activity of the Hippocampus development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC35A5, MRAS, and ANKDD1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hippocampus development activity versus SLC35A5 in LUNG_SCLC (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC35A5 →	+0.850	+0.220	<.001	<.001	3	5
URINARY_TRACT	MRAS →	+2.572	+0.277	.006	.004	3	4
OESOPHAGUS	ANKDD1A →	+1.248	+0.166	.009	.008	3	4
URINARY_TRACT	CHRNB1 →	+1.475	+0.205	.004	.005	3	4
BLOOD_Leukemia	MACF1 →	+0.938	+0.167	.001	.004	3	4
BLOOD_Leukemia	CBY3 →	+0.600	+0.193	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021766 vs SLC35A5 — LUNG_SCLC

Explore this scatter interactively →