Substantia nigra development

Across TCGA cell cohorts, RNA activity of the Substantia nigra development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCO2, PNKD, and EPHX1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Substantia nigra development activity versus SCO2 in SKIN (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SCO2 →	+0.719	+0.166	<.001	.009	3	6
KIDNEY	PNKD →	+0.876	+0.260	.009	.006	3	5
KIDNEY	EPHX1 →	+2.608	+0.192	.003	.001	3	5
BLOOD_Leukemia	SEC11A →	+0.762	+0.211	<.001	<.001	3	5
OESOPHAGUS	PPP1R9B →	+0.852	+0.199	.001	.001	3	5
OESOPHAGUS	SLC26A11 →	+0.756	+0.180	.006	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021762 vs SCO2 — SKIN

Explore this scatter interactively →