Limbic system development

Across TCGA patient cohorts, RNA activity of the Limbic system development pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THBS1, C1R, and TRADD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Limbic system development activity versus THBS1 in PDAC (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	THBS1 →	+0.884	+0.023	<.001	.001	3	5
OV	C1R →	+0.564	+0.043	.001	<.001	3	5
HNSC	TRADD →	-0.179	-0.030	.001	.007	3	5
PDAC	SPON2 →	+0.618	+0.025	.003	<.001	3	5
PDAC	IKBIP →	+0.243	+0.026	<.001	<.001	3	5
COAD	SSNA1 →	-0.272	-0.016	.009	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021761 vs THBS1 — PDAC

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