Limbic system development

Across TCGA cell cohorts, RNA activity of the Limbic system development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPC1, HERC5, and MARCHF4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPC1 grouped by Limbic system development-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GPC1 →	-2.829	-0.222	.004	.009	3	5
URINARY_TRACT	HERC5 →	-1.636	-0.253	<.001	.009	2	5
URINARY_TRACT	MARCHF4 →	-3.111	-0.257	.003	.007	3	4
PANCREAS	PPP2R2D →	+0.594	+0.212	<.001	<.001	3	4
LUNG_NSCLC_LUSC	POC1B →	+1.181	+0.272	.001	.006	2	5
BONE	TMEM14C →	-1.049	-0.236	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPC1 by Limbic system development activity — BONE

Explore this box plot interactively →