Limbic system development

Across TCGA cell cohorts, RNA activity of the Limbic system development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FXR2, ASXL1, and EIF3K, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Limbic system development activity versus FXR2 in OESOPHAGUS (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FXR2 →	+0.710	+0.228	.005	<.001	3	6
STOMACH	ASXL1 →	+1.536	+0.290	.001	.001	3	5
BLOOD_Leukemia	EIF3K →	-0.532	-0.172	<.001	<.001	3	5
BLOOD_Leukemia	FGFR1OP2 →	+0.561	+0.106	.005	.004	3	4
BLOOD_Leukemia	SLC35A5 →	+0.477	+0.136	.002	<.001	3	4
BLOOD_Myeloma	BCL10 →	+0.865	+0.157	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021761 vs FXR2 — OESOPHAGUS

Explore this scatter interactively →