Cerebellar cortex formation

Across TCGA patient cohorts, RNA activity of the Cerebellar cortex formation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSMB10_S230, STK10, and TNFAIP8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar cortex formation activity versus PSMB10_S230 in LSCC (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PSMB10_S230 →	-0.892	-0.107	.001	.002	3	7
LSCC	STK10 →	-0.347	-0.089	.001	<.001	3	6
GBM	TNFAIP8 →	-0.392	-0.039	.005	.007	3	6
GBM	FERMT3 →	-0.430	-0.052	.004	.006	3	6
GBM	FLII →	-0.186	-0.069	<.001	<.001	3	6
HNSC	NCF2 →	-0.351	-0.065	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021697 vs PSMB10_S230 — LSCC

Explore this scatter interactively →