Cerebellar cortex formation

Across TCGA cell cohorts, RNA activity of the Cerebellar cortex formation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNT7A, WHRN, and LRP6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WNT7A grouped by Cerebellar cortex formation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	WNT7A →	-0.177	-0.936	.005	.001	3	6
CNS	WHRN →	-0.460	-1.302	<.001	.001	2	6
UPPER_AERODIGESTIVE_TRACT	LRP6 →	-0.296	-1.062	.001	.002	3	5
BREAST	LHX5 →	-0.113	-0.941	.001	<.001	3	5
PANCREAS	TTLL1 →	-0.192	-1.038	<.001	<.001	3	4
BREAST	TBX2 →	-0.219	-1.186	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WNT7A by Cerebellar cortex formation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →