Cerebellar cortex formation

Across TCGA cell cohorts, RNA activity of the Cerebellar cortex formation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPT2, PPA1, and CFL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPT2 grouped by Cerebellar cortex formation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PPT2 →	+0.648	+0.978	.002	.001	3	5
SOFT_TISSUE	PPA1 →	+0.981	+1.949	<.001	<.001	3	5
LUNG_NSCLC_LUAD	CFL2 →	-1.162	-0.868	.002	.004	3	4
LUNG_NSCLC_LUSC	QRICH2 →	-1.161	-1.345	<.001	<.001	3	4
LUNG_NSCLC_LUSC	PNMA1 →	-0.931	-1.485	<.001	<.001	3	4
SOFT_TISSUE	AAK1 →	-0.964	-1.616	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPT2 by Cerebellar cortex formation activity — CNS

Explore this box plot interactively →