Cerebellar cortex formation

Across TCGA cell cohorts, RNA activity of the Cerebellar cortex formation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA0930, ZNF207, and EXOSC3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar cortex formation activity versus KIAA0930 in LUNG_SCLC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KIAA0930 →	+1.569	+1.869	.006	.002	3	1
LUNG_SCLC	ZNF207 →	-0.549	-1.483	.001	.004	3	1
LUNG_SCLC	EXOSC3 →	-0.711	-1.118	.001	.003	3	1
LUNG_SCLC	C17orf75 →	-0.950	-1.251	.001	.008	3	1
LUNG_SCLC	LUC7L3 →	-1.004	-1.052	.002	.007	3	1
LUNG_SCLC	CRACD →	-1.905	-1.829	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021697 vs KIAA0930 — LUNG_SCLC

Explore this scatter interactively →