Cerebellar cortex morphogenesis

Across TCGA patient cohorts, RNA activity of the Cerebellar cortex morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTK6, SHISA5P2, and FSIP2-AS2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar cortex morphogenesis activity versus PTK6 in UCEC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PTK6 →	+0.801	+0.401	.003	.001	3	3
UCEC	SHISA5P2 →	+0.650	+0.403	<.001	<.001	3	3
UCEC	FSIP2-AS2 →	+0.786	+0.364	.002	.003	3	3
UCEC	HUNK-AS1 →	+0.552	+0.410	.001	.003	3	3
LUAD	MAGT1 →	+0.301	+0.547	.005	.002	3	3
HNSC	WIF1 →	+0.948	+0.282	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021696 vs PTK6 — UCEC

Explore this scatter interactively →