Cerebellar cortex development

Across TCGA patient cohorts, RNA activity of the Cerebellar cortex development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD74, PRKCD, and PSME2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar cortex development activity versus CD74 in LSCC (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CD74 →	-0.604	-0.064	<.001	<.001	3	7
LSCC	PRKCD →	-0.300	-0.079	<.001	<.001	3	7
LSCC	PSME2 →	-0.365	-0.049	<.001	.001	3	7
GBM	LRRFIP1 →	-0.338	-0.051	<.001	<.001	3	7
GBM	TNFAIP8 →	-0.637	-0.039	<.001	<.001	3	6
GBM	TOR4A →	-0.526	-0.059	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021695 vs CD74 — LSCC

Explore this scatter interactively →