Cerebellar cortex development

Across TCGA patient cohorts, RNA activity of the Cerebellar cortex development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBOX5, FOXRED2, and ATPAF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar cortex development activity versus UBOX5 in GBM (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UBOX5 →	+0.325	+0.669	.004	.001	3	5
GBM	FOXRED2 →	+0.512	+0.595	.003	.006	3	4
GBM	ATPAF1 →	+0.346	+0.743	<.001	<.001	3	4
HNSC	BEX2 →	+1.110	+0.650	.006	.001	3	4
HNSC	MTARC1 →	+0.616	+0.817	.001	<.001	3	4
GBM	CARMIL3 →	+0.625	+0.595	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021695 vs UBOX5 — GBM

Explore this scatter interactively →