Cerebellar cortex development

Across TCGA cell cohorts, RNA activity of the Cerebellar cortex development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBMX, HNRNPA0, and EZH2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar cortex development activity versus RBMX in LIVER (Pearson r = -0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RBMX →	-0.604	-0.406	<.001	<.001	3	7
BLOOD_Leukemia	HNRNPA0 →	-0.599	-0.140	<.001	<.001	3	7
BLOOD_Leukemia	EZH2 →	-1.107	-0.183	<.001	<.001	3	6
BREAST	NASP →	-1.107	-0.294	<.001	<.001	3	6
LIVER	SRSF7 →	-0.718	-0.434	.008	.006	2	7
LIVER	SNRPG →	-0.840	-0.426	.003	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021695 vs RBMX — LIVER

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