Cerebellar Purkinje cell layer morphogenesis

Across TCGA cell cohorts, RNA activity of the Cerebellar Purkinje cell layer morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FMR1, MEIS1, and CACNB3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FMR1 grouped by Cerebellar Purkinje cell layer morphogenesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FMR1 →	+0.110	+0.083	.006	.005	3	3
BLOOD_Lymphoma	MEIS1 →	+0.491	+0.102	<.001	.009	3	3
BLOOD_Lymphoma	CACNB3 →	+0.457	+0.102	.004	.009	3	3
UPPER_AERODIGESTIVE_TRACT	HSPB1 →	-0.126	-0.086	.001	.002	3	3
UPPER_AERODIGESTIVE_TRACT	ERCC4 →	+0.228	+0.117	.008	.001	3	3
UPPER_AERODIGESTIVE_TRACT	OR1D5 →	-0.258	-0.093	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FMR1 by Cerebellar Purkinje cell layer morphogenesis activity — BLOOD_Myeloma

Explore this box plot interactively →