Cerebellar Purkinje cell layer morphogenesis

Across TCGA cell cohorts, RNA activity of the Cerebellar Purkinje cell layer morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AURKC, ETFA, and EFHC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar Purkinje cell layer morphogenesis activity versus AURKC in LUNG_SCLC (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AURKC →	+0.850	+1.057	.002	.004	3	4
BREAST	ETFA →	-0.708	-0.409	.004	.004	3	3
BLOOD_Leukemia	EFHC2 →	+0.798	+0.506	.001	<.001	3	3
LARGE_INTESTINE	CLK3 →	-0.682	-0.223	.001	.007	3	3
BLOOD_Leukemia	STAM →	+1.697	+0.602	.008	.005	3	2
LUNG_SCLC	COL10A1 →	+0.069	+0.693	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021692 vs AURKC — LUNG_SCLC

Explore this scatter interactively →