Cerebellar granular layer formation

Across TCGA cell cohorts, RNA activity of the Cerebellar granular layer formation pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRHBP, GTF2IRD2B, and GNA13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRHBP grouped by Cerebellar granular layer formation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CRHBP →	-0.425	-0.132	.001	.001	3	4
BLOOD_Leukemia	GTF2IRD2B →	-0.298	-0.216	<.001	.006	3	4
OESOPHAGUS	GNA13 →	+0.148	+0.146	.004	.002	3	4
BLOOD_Lymphoma	CCAR2 →	+0.323	+0.172	.008	.002	3	4
SKIN	NCR2 →	+0.167	+1.148	<.001	<.001	3	3
OVARY	TIPRL →	+0.112	+0.949	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRHBP by Cerebellar granular layer formation activity — KIDNEY

Explore this box plot interactively →