Cerebellar granular layer development

Across TCGA patient cohorts, RNA activity of the Cerebellar granular layer development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELOVL4, SNN, and PRKAR1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar granular layer development activity versus ELOVL4 in GBM (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ELOVL4 →	+0.466	+0.871	.003	<.001	3	4
GBM	SNN →	+0.622	+0.865	.001	.001	3	4
GBM	PRKAR1B →	+0.859	+1.004	<.001	<.001	3	4
GBM	DMD →	+0.738	+0.889	.007	<.001	3	4
GBM	CD8B2 →	+0.074	+0.943	.006	<.001	3	4
BRCA	DGKZ →	+0.556	+0.191	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021681 vs ELOVL4 — GBM

Explore this scatter interactively →