Cerebellar granular layer development

Across TCGA cell cohorts, RNA activity of the Cerebellar granular layer development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRAT1, NAA60, and STIMATE, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FRAT1 grouped by Cerebellar granular layer development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FRAT1 →	+0.657	+0.961	.008	<.001	3	6
OVARY	NAA60 →	+0.590	+0.960	.001	.003	3	6
SOFT_TISSUE	STIMATE →	-1.103	-1.816	<.001	<.001	3	4
SOFT_TISSUE	GALNT2 →	-1.398	-1.384	.002	.002	3	4
SOFT_TISSUE	OR52I1 →	-0.035	-1.512	.001	<.001	3	4
LUNG_NSCLC_LUSC	SNW1 →	-0.692	-1.415	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FRAT1 by Cerebellar granular layer development activity — BREAST

Explore this box plot interactively →