Cerebellar granular layer development

Across TCGA cell cohorts, RNA activity of the Cerebellar granular layer development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DBP, SPATA1, and EBPL, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar granular layer development activity versus DBP in LUNG_SCLC (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DBP →	+1.588	+1.714	.001	<.001	3	1
LUNG_SCLC	SPATA1 →	+0.595	+1.601	.005	.001	3	1
LUNG_SCLC	EBPL →	-0.625	-1.072	.006	.009	3	1
LUNG_SCLC	LINS1 →	-1.046	-1.619	<.001	.003	3	1
LUNG_SCLC	PIP5K1A →	-0.658	-1.096	.006	.007	3	1
LUNG_SCLC	RAD9B →	+1.056	+1.248	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021681 vs DBP — LUNG_SCLC

Explore this scatter interactively →