Cerebellar Purkinje cell layer development

Across TCGA cell cohorts, RNA activity of the Cerebellar Purkinje cell layer development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCL, BCL9, and NSL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar Purkinje cell layer development activity versus FANCL in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	FANCL →	-1.028	-0.172	.002	.002	3	6
CNS	BCL9 →	-0.911	-0.171	.003	.002	3	5
CNS	NSL1 →	-0.475	-0.150	.001	.002	3	5
BONE	SMARCA4 →	-1.310	-0.221	<.001	.005	3	5
SKIN	ILF3 →	-0.512	-0.139	.005	.003	3	5
UPPER_AERODIGESTIVE_TRACT	NONO →	-0.637	-0.147	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021680 vs FANCL — UPPER_AERODIGESTIVE_TRACT

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