Nerve development

Across TCGA cell cohorts, RNA activity of the Nerve development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBL, TRAP1, and MRPL45, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nerve development activity versus FBL in BONE (Pearson r = -0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FBL →	-0.845	-1.680	<.001	<.001	3	6
BONE	TRAP1 →	-1.784	-1.685	<.001	<.001	3	6
SKIN	MRPL45 →	-0.445	-1.205	.001	<.001	3	6
CNS	B4GALT1 →	+1.079	+1.443	.001	<.001	3	6
BONE	KCNQ4 →	-1.607	-1.563	<.001	.002	3	5
BREAST	LRPPRC →	-0.833	-1.070	.001	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021675 vs FBL — BONE

Explore this scatter interactively →