Nerve development

Across TCGA cell cohorts, RNA activity of the Nerve development pathway is significantly associated with the protein abundance of multiple proteins, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CTNNB1, CCT3, and HSPA4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nerve development activity versus CTNNB1 in OESOPHAGUS (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CTNNB1 →	+1.696	+0.960	<.001	<.001	3	10
BONE	CCT3 →	-0.847	-1.280	<.001	<.001	3	10
LUNG_SCLC	HSPA4 →	-0.789	-0.823	<.001	.003	3	9
BONE	CCT7 →	-0.799	-0.996	<.001	<.001	3	9
LUNG_SCLC	GART →	-0.815	-0.972	<.001	.004	3	8
OESOPHAGUS	NME1 →	-1.313	-0.813	<.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021675 vs CTNNB1 — OESOPHAGUS

Explore this scatter interactively →