Lateral ventricle development

Across TCGA patient cohorts, RNA activity of the Lateral ventricle development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS27P14, ARSDP1, and RPL21P36, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lateral ventricle development activity versus RPS27P14 in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPS27P14 →	+0.583	+0.225	<.001	<.001	3	4
BRCA	ARSDP1 →	+0.220	+0.228	.002	.002	3	3
BRCA	RPL21P36 →	+0.180	+0.259	.002	<.001	3	3
BRCA	RPL13AP2 →	+0.512	+0.181	.001	.008	3	3
BRCA	PKMP4 →	+0.792	+0.290	.001	.001	3	3
BRCA	NPM1P5 →	+0.505	+0.342	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021670 vs RPS27P14 — BRCA

Explore this scatter interactively →