Lateral ventricle development

Across TCGA cell cohorts, RNA activity of the Lateral ventricle development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFNB2, TNS2, and FCGRT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lateral ventricle development activity versus EFNB2 in SOFT_TISSUE (Pearson r = -0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	EFNB2 →	-2.730	-1.833	.003	<.001	3	4
LUNG_SCLC	TNS2 →	-1.144	-1.593	.004	<.001	3	3
BLOOD_Lymphoma	FCGRT →	+3.816	+1.709	<.001	<.001	3	3
BLOOD_Lymphoma	MRPL17 →	-1.555	-1.320	.002	.003	3	3
BLOOD_Leukemia	PTPN22 →	+2.203	+1.384	.003	.001	3	3
BLOOD_Leukemia	FAM161B →	+0.818	+1.124	.002	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021670 vs EFNB2 — SOFT_TISSUE

Explore this scatter interactively →