Vestibulocochlear nerve formation

Across TCGA patient cohorts, RNA activity of the Vestibulocochlear nerve formation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK2, LCP2, and SERPINB9, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vestibulocochlear nerve formation activity versus DOCK2 in OV (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DOCK2 →	-0.479	-0.153	.001	<.001	3	9
HNSC	LCP2 →	-0.527	-0.224	<.001	<.001	3	9
UCEC	SERPINB9 →	-0.467	-0.188	.001	.001	3	9
HNSC	WDFY4 →	-0.485	-0.177	<.001	<.001	3	9
PDAC	ITGAL →	-0.635	-0.114	<.001	<.001	3	9
HNSC	STAT1 →	-0.660	-0.227	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021650 vs DOCK2 — OV

Explore this scatter interactively →