Vestibulocochlear nerve formation

Across TCGA cell cohorts, RNA activity of the Vestibulocochlear nerve formation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN15, HIRIP3, and ACTG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLDN15 grouped by Vestibulocochlear nerve formation-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CLDN15 →	+1.099	+1.432	<.001	.002	2	5
SOFT_TISSUE	HIRIP3 →	-0.848	-1.057	.002	.003	3	4
PANCREAS	ACTG1 →	+0.697	+0.343	.001	.002	3	4
BLOOD_Leukemia	SATB2 →	+1.550	+0.809	.001	.007	3	4
KIDNEY	KMT5B →	-0.464	-1.002	.003	.004	3	4
KIDNEY	GPATCH3 →	-0.868	-1.506	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLDN15 by Vestibulocochlear nerve formation activity — BLOOD_Lymphoma

Explore this box plot interactively →