Vestibulocochlear nerve morphogenesis

Across TCGA patient cohorts, RNA activity of the Vestibulocochlear nerve morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYFIP1, RPS17P14, and PLK3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vestibulocochlear nerve morphogenesis activity versus CYFIP1 in CCRCC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CYFIP1 →	+0.185	+0.602	.005	<.001	3	4
PDAC	RPS17P14 →	-0.165	-0.509	.001	.001	3	3
CCRCC	PLK3 →	+0.496	+0.633	.007	.004	3	3
CCRCC	ACTB →	+0.250	+0.554	.003	.003	3	3
LSCC	NRP2 →	+0.870	+0.680	<.001	.001	3	3
BRCA	SEPTIN11 →	+0.611	+0.319	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021648 vs CYFIP1 — CCRCC

Explore this scatter interactively →