Vestibulocochlear nerve morphogenesis

Across TCGA patient cohorts, RNA activity of the Vestibulocochlear nerve morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL11A1, UCKL1_S539, and EVI5_S778, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vestibulocochlear nerve morphogenesis activity versus COL11A1 in GBM (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL11A1 →	+0.725	+0.152	.001	<.001	3	3
BRCA	UCKL1_S539 →	-0.667	-0.288	<.001	<.001	3	3
GBM	EVI5_S778 →	+0.353	+0.138	<.001	<.001	3	3
OV	NRP2 →	+0.540	+0.545	.004	.002	2	4
OV	RCN1 →	-0.671	-0.653	<.001	<.001	3	3
UCEC	SPAG9_S1188 →	-0.618	-1.078	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021648 vs COL11A1 — GBM

Explore this scatter interactively →