Vestibulocochlear nerve morphogenesis

Across TCGA cell cohorts, RNA activity of the Vestibulocochlear nerve morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHURC1-FNTB, PHKA1, and CAV3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHURC1-FNTB grouped by Vestibulocochlear nerve morphogenesis-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CHURC1-FNTB →	-0.218	-1.589	.004	.003	3	4
BONE	PHKA1 →	+0.378	+2.330	.001	<.001	3	4
CNS	CAV3 →	-0.244	-0.135	<.001	.009	3	4
BONE	PLGRKT →	+0.190	+2.203	.002	<.001	3	3
BONE	PRKD3 →	+0.300	+2.014	.006	.001	3	3
BONE	CCDC91 →	-0.500	-2.221	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHURC1-FNTB by Vestibulocochlear nerve morphogenesis activity — BONE

Explore this box plot interactively →