Vestibulocochlear nerve morphogenesis

Across TCGA cell cohorts, RNA activity of the Vestibulocochlear nerve morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRP2, NRP1, and ARSJ, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vestibulocochlear nerve morphogenesis activity versus NRP2 in PANCREAS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NRP2 →	+3.280	+0.407	<.001	.003	3	16
SOFT_TISSUE	NRP1 →	+3.496	+1.155	<.001	<.001	3	14
BONE	ARSJ →	+2.619	+1.644	<.001	<.001	3	9
BONE	HIF1A →	+2.035	+1.614	<.001	<.001	3	8
BONE	SRPX2 →	+1.972	+1.236	<.001	<.001	3	8
SOFT_TISSUE	RUNX2 →	+1.977	+0.997	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021648 vs NRP2 — PANCREAS

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