Central nervous system maturation

Across TCGA patient cohorts, RNA activity of the Central nervous system maturation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADGRG1, SIPA1, and STK10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Central nervous system maturation activity versus ADGRG1 in OV (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ADGRG1 →	+0.650	+0.089	.001	<.001	3	5
GBM	SIPA1 →	-0.240	-0.083	<.001	<.001	3	5
GBM	STK10 →	-0.420	-0.106	<.001	<.001	3	5
BRCA	CD44_S697 →	-0.775	-0.064	<.001	.003	3	5
BRCA	CD48 →	-0.698	-0.056	<.001	.004	3	5
HNSC	CCL5 →	-0.694	-0.092	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021626 vs ADGRG1 — OV

Explore this scatter interactively →