Cranial nerve structural organization

Across TCGA patient cohorts, RNA activity of the Cranial nerve structural organization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FN1, SULF1, and C1R, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cranial nerve structural organization activity versus FN1 in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FN1 →	+1.246	+0.124	<.001	<.001	3	9
LSCC	SULF1 →	+0.879	+0.114	<.001	<.001	3	8
OV	C1R →	+0.703	+0.094	<.001	<.001	3	8
COAD	COL12A1 →	+0.769	+0.072	<.001	<.001	2	9
OV	COL3A1 →	+0.906	+0.122	<.001	<.001	3	8
OV	COL5A2 →	+0.864	+0.097	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021604 vs FN1 — OV

Explore this scatter interactively →