Cranial nerve structural organization

Across TCGA patient cohorts, RNA activity of the Cranial nerve structural organization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDIL3, FN1, and CDH11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cranial nerve structural organization activity versus EDIL3 in GBM (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EDIL3 →	+1.220	+0.343	<.001	<.001	3	4
LUAD	FN1 →	+0.690	+0.508	.007	.006	2	5
LUAD	CDH11 →	+0.692	+0.595	<.001	<.001	3	4
LSCC	SYDE1 →	+0.531	+0.521	.001	<.001	3	3
LSCC	POGLUT3 →	+0.462	+0.494	.009	.009	3	3
LSCC	COL5A3 →	+0.808	+0.459	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021604 vs EDIL3 — GBM

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