Cranial nerve formation

Across TCGA patient cohorts, RNA activity of the Cranial nerve formation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CARMIL2_S1381, ARID5A_S463, and CD38, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cranial nerve formation activity versus CARMIL2_S1381 in LSCC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CARMIL2_S1381 →	-0.806	-0.073	<.001	<.001	3	6
LUAD	ARID5A_S463 →	-0.544	-0.119	<.001	<.001	3	6
BRCA	CD38 →	-0.659	-0.067	.002	.001	3	6
HNSC	SH2D1A →	-0.471	-0.070	<.001	<.001	3	5
LSCC	DOCK10_S1257 →	-0.691	-0.068	<.001	<.001	3	5
HNSC	FYB1 →	-0.344	-0.061	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021603 vs CARMIL2_S1381 — LSCC

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