Cranial nerve formation

Across TCGA cell cohorts, RNA activity of the Cranial nerve formation pathway is significantly associated with the drug response of multiple features, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are QS11, GSK2578215A, and Vismodegib, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, QS11 grouped by Cranial nerve formation-low versus -high activity in BREAST.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	QS11 →	+1.090	+0.319	.013	.002	3	3
OVARY	GSK2578215A →	+0.393	+1.306	.042	.040	3	3
UPPER_AERODIGESTIVE_TRACT	Vismodegib →	+0.293	+1.127	.008	.010	3	2
UPPER_AERODIGESTIVE_TRACT	Crizotinib →	+0.628	+0.912	.009	.029	3	2
UPPER_AERODIGESTIVE_TRACT	YK-4-279 →	+0.680	+1.275	.043	.006	3	2
BREAST	FGFR_0939 →	+0.814	+0.291	.023	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

QS11 by Cranial nerve formation activity — BREAST

Explore this box plot interactively →