Cranial nerve morphogenesis

Across TCGA patient cohorts, RNA activity of the Cranial nerve morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSHZ3, UNC5B, and COL6A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cranial nerve morphogenesis activity versus TSHZ3 in HNSC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TSHZ3 →	+0.401	+0.461	.006	.003	3	5
LUAD	UNC5B →	+0.505	+0.413	.003	.003	3	4
UCEC	COL6A1 →	+0.733	+0.382	.006	<.001	3	4
BRCA	MEIS3 →	+0.986	+0.780	.002	<.001	2	5
GBM	SEPTIN4 →	+0.662	+0.546	<.001	<.001	3	4
OV	NRP2 →	+0.951	+0.463	.004	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021602 vs TSHZ3 — HNSC

Explore this scatter interactively →