Cranial nerve morphogenesis

Across TCGA cell cohorts, RNA activity of the Cranial nerve morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN31, SLC50A1, and NRP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cranial nerve morphogenesis activity versus TSPAN31 in BREAST (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TSPAN31 →	-1.881	-1.233	.008	.004	3	4
SKIN	SLC50A1 →	-0.828	-1.385	<.001	.002	3	3
CNS	NRP2 →	+2.053	+1.386	<.001	<.001	3	3
CNS	ARL6IP5 →	+1.037	+1.178	.001	.004	3	3
CNS	CCS →	-0.632	-1.399	.003	<.001	3	3
CNS	APRT →	-0.888	-1.160	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021602 vs TSPAN31 — BREAST

Explore this scatter interactively →