Ventricular system development

Across TCGA patient cohorts, RNA activity of the Ventricular system development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLE2, DCLRE1B, and BRIP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular system development activity versus POLE2 in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	POLE2 →	+0.598	+0.570	<.001	<.001	3	3
BRCA	DCLRE1B →	+0.552	+0.561	<.001	.001	3	3
UCEC	BRIP1 →	+0.829	+0.584	<.001	.005	3	3
BRCA	DNA2 →	+0.627	+0.539	<.001	<.001	3	3
PDAC	BCL2L14 →	-0.459	-0.653	.004	<.001	3	3
LSCC	H2BP2 →	+0.146	+0.625	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021591 vs POLE2 — BRCA

Explore this scatter interactively →