Ventricular system development

Across TCGA cell cohorts, RNA activity of the Ventricular system development pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEPTIN3, ASF1B, and BHLHE40, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEPTIN3 grouped by Ventricular system development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SEPTIN3 →	-1.583	-1.312	.003	<.001	3	4
CNS	ASF1B →	-1.416	-1.116	.002	.005	3	4
BLOOD_Leukemia	BHLHE40 →	-2.755	-1.170	<.001	.006	2	5
PANCREAS	KIF16B →	-1.100	-1.300	.003	<.001	3	4
LARGE_INTESTINE	TTBK2 →	-0.872	-1.198	<.001	<.001	3	4
LARGE_INTESTINE	PSIP1 →	-0.807	-0.945	.003	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEPTIN3 by Ventricular system development activity — STOMACH

Explore this box plot interactively →