Ventricular system development

Across TCGA cell cohorts, RNA activity of the Ventricular system development pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF10C, CLVS2, and PABPC4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNFRSF10C grouped by Ventricular system development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TNFRSF10C →	+0.291	+2.037	.009	<.001	3	4
SOFT_TISSUE	CLVS2 →	+0.435	+2.112	<.001	<.001	3	4
LUNG_NSCLC_LUSC	PABPC4 →	-0.263	-0.677	.001	.004	3	3
SOFT_TISSUE	GP5 →	-0.249	-2.112	<.001	<.001	3	3
SOFT_TISSUE	TMLHE →	+0.169	+2.023	.007	<.001	3	3
SOFT_TISSUE	DLG1 →	+0.410	+2.182	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNFRSF10C by Ventricular system development activity — SOFT_TISSUE

Explore this box plot interactively →