Hindbrain morphogenesis

Across TCGA patient cohorts, RNA activity of the Hindbrain morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMTM7, ZNF134, and ZNF793-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hindbrain morphogenesis activity versus CMTM7 in GBM (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CMTM7 →	-0.456	-0.716	<.001	<.001	3	4
CCRCC	ZNF134 →	+0.375	+0.647	.001	.001	3	4
CCRCC	ZNF793-AS1 →	+0.387	+0.571	<.001	<.001	3	4
CCRCC	LY75 →	-0.697	-0.725	<.001	.003	3	4
HNSC	ENPP3 →	+0.436	+0.260	.001	.001	3	4
HNSC	SYNPR-AS1 →	+0.806	+0.410	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021575 vs CMTM7 — GBM

Explore this scatter interactively →