Hindbrain morphogenesis

Across TCGA cell cohorts, RNA activity of the Hindbrain morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLN1, GLIPR1, and TFE3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLN1 grouped by Hindbrain morphogenesis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TLN1 →	-0.663	-1.229	<.001	<.001	3	5
SKIN	GLIPR1 →	-2.535	-1.051	.001	.001	3	5
SOFT_TISSUE	TFE3 →	-1.102	-1.323	.006	.002	3	5
BLOOD_Leukemia	PIGL →	+0.631	+0.969	.008	.001	3	5
BREAST	RAB3D →	+1.527	+0.858	<.001	.002	3	4
BREAST	MAP7 →	+1.388	+0.701	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLN1 by Hindbrain morphogenesis activity — SKIN

Explore this box plot interactively →