Hindbrain morphogenesis

Across TCGA cell cohorts, RNA activity of the Hindbrain morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IDI1, CNOT3, and MZF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hindbrain morphogenesis activity versus IDI1 in LUNG_NSCLC_LUSC (Pearson r = -0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	IDI1 →	-1.094	-0.183	.001	.001	3	4
BONE	CNOT3 →	-0.512	-0.165	.005	.001	3	4
BONE	MZF1 →	-1.076	-0.182	<.001	.008	3	4
BLOOD_Leukemia	RO60 →	-0.716	-0.137	.009	.003	3	4
BLOOD_Leukemia	ATP7A →	-0.791	-0.136	.007	.004	3	4
STOMACH	SP3 →	-0.673	-0.173	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021575 vs IDI1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →