Glossopharyngeal nerve development

pathway activity — cross-omics
GO:0021563Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Glossopharyngeal nerve development pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCBP2L, NAV2, and ZBTB16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACNCBP2L →-0.178-0.302.009.00235
UCECNAV2 →+0.871+0.291<.001<.00135
PDACZBTB16 →-1.259-0.261<.001.00933
PDACTRPV6 →-0.791-0.237.005.00333
PDACRIC3 →-0.797-0.341<.001<.00133
PDACANXA4 →-0.536-0.240<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration