Trigeminal nerve development

Across TCGA patient cohorts, RNA activity of the Trigeminal nerve development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FNBP1, HCLS1, and GRAP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trigeminal nerve development activity versus FNBP1 in BRCA (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FNBP1 →	-0.363	-0.095	<.001	<.001	3	8
LSCC	HCLS1 →	-0.413	-0.120	<.001	<.001	3	8
LSCC	GRAP2 →	-0.518	-0.138	<.001	<.001	3	7
CCRCC	LCP1 →	-0.488	-0.138	<.001	<.001	3	7
BRCA	SH2D1A →	-0.701	-0.093	.001	<.001	3	7
CCRCC	SKAP1 →	-0.650	-0.110	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021559 vs FNBP1 — BRCA

Explore this scatter interactively →