Trigeminal nerve development

Across TCGA patient cohorts, RNA activity of the Trigeminal nerve development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NBPF26, NISCH, and RNU6-1009P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trigeminal nerve development activity versus NBPF26 in LSCC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NBPF26 →	+0.468	+0.388	<.001	.008	3	3
CCRCC	NISCH →	+0.278	+0.949	.007	.001	3	3
CCRCC	RNU6-1009P →	-0.423	-0.638	.001	.003	3	3
BRCA	RNU6-11P →	-0.381	-0.477	.006	.001	3	3
PDAC	PKHD1 →	+1.250	+0.702	.003	<.001	3	3
LUAD	ZNF700 →	+0.262	+0.465	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021559 vs NBPF26 — LSCC

Explore this scatter interactively →