Trigeminal nerve development

Across TCGA cell cohorts, RNA activity of the Trigeminal nerve development pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLIC5, CNP, and ADH1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLIC5 grouped by Trigeminal nerve development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CLIC5 →	-0.271	-0.173	.004	<.001	3	4
PANCREAS	CNP →	+0.183	+0.151	.001	.001	3	4
BONE	ADH1B →	+0.259	+0.153	.004	<.001	3	4
LARGE_INTESTINE	RNF20 →	-0.289	-0.540	.001	.005	3	4
LUNG_NSCLC_LUAD	ARHGAP32 →	-0.224	-0.166	.004	.003	3	4
SOFT_TISSUE	SEPSECS →	-0.164	-0.256	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLIC5 by Trigeminal nerve development activity — PANCREAS

Explore this box plot interactively →