Trigeminal nerve development

Across TCGA cell cohorts, RNA activity of the Trigeminal nerve development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLXNA3, NRP2, and NRP1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trigeminal nerve development activity versus PLXNA3 in BLOOD_Myeloma (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PLXNA3 →	+2.252	+1.431	<.001	<.001	3	14
LIVER	NRP2 →	+2.466	+0.243	<.001	<.001	3	13
LUNG_NSCLC_LUSC	NRP1 →	+3.892	+0.283	<.001	.002	3	12
LUNG_NSCLC_LUAD	SEMA3A →	+2.030	+0.139	<.001	<.001	3	9
LIVER	BMP1 →	+1.956	+0.234	.002	.007	3	9
BREAST	TFAP2A →	+1.944	+0.337	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021559 vs PLXNA3 — BLOOD_Myeloma

Explore this scatter interactively →