Trigeminal nerve development

Across TCGA cell cohorts, RNA activity of the Trigeminal nerve development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTN4RL2, CRYM, and GATA3, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trigeminal nerve development activity versus RTN4RL2 in OVARY (Pearson r = -0.92).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RTN4RL2 →	-2.260	-1.718	.006	.006	3	2
OVARY	CRYM →	+3.109	+1.644	<.001	<.001	3	1
OVARY	GATA3 →	+0.770	+1.644	<.001	<.001	3	1
OVARY	ENO2 →	+3.550	+1.640	.003	.004	3	1
OVARY	TIMMDC1 →	-1.100	-1.492	.001	.004	3	1
OVARY	CXCR4 →	+4.574	+1.644	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021559 vs RTN4RL2 — OVARY

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